梁斌


研究员/ liangb73@ynu.edu.cn /脂滴生物学、脂肪肝发病机理及治疗

(博士、研究员)

 

个人情况介绍

    梁斌,博士,研究员(二级),博士生导师。2010年入选中国科学院百人计划2014年入选云南省高端科技人才从事“脂滴生物学与脂肪肝发病机理”研究。中国生物物理学会理事、代谢生物学分会理事,国际脂代谢领域知名期刊Journal of Lipid Research编委、Biophysics Reports 编委和青年编委主任。主持科技部国家重点研发计划重点专项(课题组长),国家基金委-云南省联合基金(2项)、重大研究计划、面上项目(3项),中科院先导专项B类项目。以通讯作者第一作者在Cell MetabolismJournal of Cell BiologyNature CommunicationsCell Reports等国际著名期刊发表SCI论文50多篇。获2020-2021爱思唯尔(Elsevier)中国金色开放获取高下载论文作者


 

教育及工作经历

2001.09-2004.07  复旦大学生命科学院遗传所,博士学位

1999.09-2001.07  云南大学生化学院,硕士学位

1990.09-1994.06  云南大学生物系,学士学位

 


2019.09-至今  云南大学生命科学中心/生命科学学院,研究员,博导

2010.08-2019.08   中科院昆明动物研究所脂类代谢与疾病学科组负责人研究员,博导

2006.10-2010.07 美国华盛顿州立大学(Washington State University), 博士后,研究助理教授

2006.07-2006.10  美国爱因斯坦医学院(Albert Einstein College of Medicine ), 博士后

2004.12-2006.07 美国加州大学尔湾分校(University of California, Irvine), 博士后

1994.07-2004.11  云南省农科院农作物品种资源站,研究实习员、助理研究员


研究方向

1. 脂滴生物学

脂滴是重要的细胞器,存在于所有真核生物和部分原核生物。脂滴与其它细胞器(如内质网、线粒体、细胞核等)互作,响应胞内外环境变化,动态调节细胞的脂质代谢和能量平衡,参与生物体的生长、发育、生殖、衰老、抗逆境等。脂滴在脂肪组织和非脂肪组织(如肝脏)中大量沉积,导致肥胖、脂肪肝、糖尿病等代谢性疾病。我们利用秀丽线虫小鼠等模式生物,重点研究1)脂滴形成增大、融合和分解的分子机理2)脂滴蛋白靶向脂滴的分子机理;3)不同生理或病理条件下脂滴其它细胞器互作维持细胞和机体脂质代谢和能量稳态的机理进而揭示脂代谢紊乱相关疾病如脂肪肝的发病机理,寻找新的疾病标志物和治疗靶标。


2. 脂肪肝发病机理及治疗

肝脏是重要的代谢器官临床上当肝脏中多于5%的肝细胞出现脂滴积累时,即为肝脏脂肪变性。随着肝脏中脂肪过多的积累,脂毒性、胰岛素抵抗等多种因素作用下,出现小叶炎症和肝细胞损伤等,肝脏脂肪变性发展为脂肪性肝炎;如果脂肪性肝炎中出现胶原沉积则发展形成肝脏纤维化,继续恶化则导致肝硬化和肝癌。

我们利用脂肪肝细胞和动物模型,通过转录组、蛋白质组、代谢组等,重点开展脂质代谢和脂滴在脂肪肝中的作用机理研究,寻找新的疾病标志物和治疗靶标,肝脏疾病治疗药物的筛选、评价和作用机理研究。我们新发现一个脂肪肝致病因子——钙结合蛋白S100A11,其表达和脂肪肝的发病进展正相关,S100A11过表达导致脂肪肝和肝纤维化。目前正在研究S100A11在肝脏及其它代谢性疾病中的作用机理。



正在承担的科研项目

1. 国家自然科学基金面上项目,“S100A11-SREBP2-胆固醇环路在非酒精性脂肪肝炎(NASH)中的作用机理”,32371232,项目负责人,2024/01-2027/12

2. 科技部国家重点研发计划重点专项,“应激对组织器官代谢稳态和发育的调控作用与机制”,课题三“应激调控细胞器稳态的代谢效应与机制”,2018YPA0800703,课题负责人,2019/07-2024/06

 


部分研究论文#通讯作者*第一作者. 按最近的发表年代排序):


1. Lin Fu*, Jingjing Zhang*, Yanli Wang*, Huiyin Wu*, Chunxia Li, Jing Liu, Haizhen Wang, Jirong Li, Xue Jiang, Pingsheng Liu#, Yingjie Wu#, Xiaoju Zou#, Bin Liang#. LET-767 determines lipid droplet protein targeting and lipid homeostasis. Journal of Cell Biology. 2024 (6): e202311024.


2. Linqiang Zhang*, Yongqiong Shi*, Bin Liang#, and Xi Li#. An overview of the cholesterol metabolism and its proinflammatory role in the development of MASLD. Hepatology Communications. 8(5):e0434, May 2024.


3. Yanli Wang*, Chunxia Li*, Jingjing Zhang*, Xiumei Xu, Lin Fu, Jie Xu, Hong Zhu, Ying Hu, Chengbin Li, Mengjie Wang, Yingjie Wu#, Xiaoju Zou#, Bin Liang#. Polyunsatured fatty acids promote a fast fusion of lipid droplets in Caenorhabditis elegans. Journal of Biological Chemistry. 2022, 298(8):102179.


4. Rendan Yang*, Yamei Li*, Yanli Wang, Jingjing Zhang, Qijing Fan, Jianlin Tan, Weizhen Li#, Xiaoju Zou#, Bin Liang#. NHR-80 Senses the Mitochondrial UPR to Rewire Citrate Metabolism for Lipid Accumulation in Caenorhabditis elegans. Cell Reports, 2022, 38(2):110206.


5. Bin Liang#, Jennifer Watts#. Less is more: Seipin, phosphocoline, and embrogenesis. Life Metabolism. 2022.  (Invited commentary)


6.Tingting Zhu*, Linqiang Zhang*, Chengbin Li, Xiaoqiong Tan, Jing Liu,Huiqin Li, Qijing Fan, Zhiguo Zhang, Mingfeng Zhan, Lin Fu, Jinbo Luo, Jiawei Geng#, Yingjie Wu#, Xiaoju Zou#,Bin Liang#. The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-β signaling. Journal of Genetics and Genomics. 2022, 49(4):338-349.

7. Jingjing Zhang*, Ying Hu*, Yanli Wang*, Lin Fu, Xiumei Xu, Chunxia Li, Jie Xu, Chengbin Li, Linqiang Zhang, Rendan Yang, Xue Jiang, Yingjie Wu, Pingsheng Liu#, Xiaoju Zou#, Bin Liang#. mmBCFA C17iso ensures Endoplasmic Reticulum integrity for lipid droplet growth. Journal of Cell Biology. 2021; 220(11):e202102122. (Recommended in Faculty Opinions).

8. Linqiang Zhang*, Zhiguo Zhang*, Chengbin Li*, Tingting Zhu, Jing Gao, Hu Zhou, Yingzhuan Zheng, Qing Chang, Mingshan Wang, Jieyu Wu, Liyuan Ran, Yingjie Wu#, Huilai Miao#, Xiaoju Zou#, Bin Liang#. S100A11 promotes liver steatosis via FOXO1-mediated autophagy and lipogenesis. Cell Mol Gastroenterol Hepatol. 2021;11(3):697-724.(同期配发评论文章)(2020-2021爱思唯尔(Elsevier)中国金色开放获取高下载论文)

9. Yanhu Liu*, Lu Wang*, Zhiguo Zhang*, Newton O. Otecko, Saber Khederzadeh, Yongqin Dai, Bin Liang#, Guodong Wang#, Yaping Zhang#. Whole-genome sequencing reveals lactase persistence adaptation in European dogs. Molecular Biology and Evolution. 2021. (Recommended in Faculty Opinions).

10. Shuang Wang*, Ning Wang*, Bin Yu, Mingxing Cao, Yanlong Wang, Yuqi Guo, Yanli Zhang, Ping Zhang, Bin Liang#, Xin Li#, Yingjie Wu#. Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model. Oncogene. 2019, 38(36): 6338-6353.

11. Jieyu Wu*, Xue Jiang*, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Lingqiang Zhang, Yuru Zhang, Yanli Wang, Xiaoju Zou#, Bin Liang#. PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. Nature Communications. 2018, 9(1):1195.

12. Junlong Wang*, Shimeng Xu*, Jing Gao*, Linqiang Zhang, Zhiguo Zhang, Wenhui Yang, Hu Zhou#, Pingsheng Liu#, Bin Liang#. SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys. American Journal of Physiology- Endocrinology and Metabolism, 2018, 315(2):E294-E306.

13. Baoshen He*, Jingjing Zhang*, Yanli Wang, Yamei Li, Xiaoju Zou#, Bin Liang#. Identification of cytochome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. BBA-Molecular and Cell Biology of Lipids, 2018, 1863(3): 235–246.

14. Jingjing Zhang, Junjun Hao, Yuru Zhang, Yanli Wang, Mingyi Li, Huilai Miao, Xiaoju Zou#, Bin Liang#. Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans. Journal of Lipid Research. 2017, 58, 2017, 1845-1854 (封面文章).

15. Haizhen Wang*, Xue Jiang*, Jieyu Wu, Linqing Zhang, Jingfei Huang,Yuru Zhang, Xiaoju Zou#, Bin Liang#. Iron overload coordinately promotes ferritin expression and fat accumulation in Caenorhabditis elegans. Genetics, 2016, 203(1): 241-253 (Comments by GENES to GENOMES).

16. Linqiang Zhang*, Xiaoyun Wu*, Shasha Liao*, Yunhai Li, Zhiguo Zhang, Qing Chang, Ruyue Xiao, Bin Liang#. Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of nonalcoholic fatty liver disease. Biology Open, 2016, 5: 1545-1552.

17. Yuru Zhang*, Haizhen Wang*, Jingjing Zhang* ,Ying Hu*, Linqiang Zhang, Xiaoyun Wu, Xiong Su, Tingting Li, Xiaoju Zou#, Bin Liang#. Cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. BBA- Molecular and Cell Biology of Lipids, 2016, 1861(4):310-319.

18. Shi X*, Li J*, Zou X, Greggain J, Rodkaer SV, Faergeman NJ, Liang B#, Watts JL#. Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase. Journal of Lipid Research. 2013, 54(9):2504-2514.

19. Yuru Zhang, Xiaoju zou, Yihong Ding, Haizhen Wang, Xiaoyun Wu, Bin Liang#. Comparative Genomics and Functional Study of Lipid Metabolic Genes in Caenorhabditis elegans. BMC Genomics. 2013, 14:164. (Highly accessed)

20. Bin Liang, Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze#. Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Cell Metabolism, 2006, 4(6):429-440.(同期被评论)




研究团队

工作人员:

王彦利  博士,助理研究员

张静静  博士,助理研究员

 静  博士助理研究员

何姚梅  博士,博士后

 

在读研究生:

博士研究生:付林、李成斌、詹铭锋、李春霞、吴慧银、范琪婧、鲁宏升、孙岩波

硕士研究生:魏子珍、王梦婕、李季蓉、申云骞、曾筝、梁宇、彭彬、李志豪、王亚军、姚亚南、徐尧