罗开珺


教授/ kaijun_luo@ynu.edu.cn/免疫反应与细胞通讯调控机制

罗开珺  教授 

云南省病毒与免疫国际联合实验室 主任

430B7

海燕策略研究中心方向:细胞生物学与生物化学


个人简历

2024年《病毒学》课程认定为省级线下一流本科课程

2023年度获国家重点领域教学资源建设《病毒学》课程建设优秀团队和优秀专家表彰

2023年任云南省病毒与免疫国际联合实验室 主任

2022教育部重点领域教学资源建设-昆虫病毒知识领域专家协助组成员

2022年被认定为无党派人士

2020年获云南省自然科学奖二等奖

2020年度获课堂教学优秀奖

2018年评为东陆学者

2018任云南省高校细胞通讯调控国际合作重点实验室 主任

2017年晋升为三级教授

2016年荣获伍达观优秀教师奖先进奖

2010年云南省引进高层次人才

2010/08 – 至今,云南大学,生命科学学院,教授

2019/01 - 2019/12, 美国得州大学,圣安东尼奥健康科学中心,生物化学与结构生物学系,访问学者

2013/03 - 2013/06,  法国马赛大学,法国国家免疫研究中心,高级访问学者

2006/10 - 2009/07, 美国克莱蒙森大学,昆虫系,细胞生物学实验室,博士后

2001/09 - 2006/06,中山大学,生命科学学院,硕博连读,博士

2003/07 - 2006/07, 云南省农业科学院,农业资源与环境研究所,副研究员

1998/07 - 2003/06, 云南省农业科学院,植物保护研究所,助理研究员

1992/07 - 1998/06, 云南省农业科学院,植物保护研究所,实习研究员

1988/09 - 1992/06, 云南师范大学,生物系,理学学士


主要研究方向:病毒-细胞通讯-免疫机制

茧蜂病毒-Innexin-hemichannel-免疫抑制相互作用机制

以无脊椎动物寄生蜂病毒-寄生蜂-寄主作为研究模式,研究在茧蜂病毒免疫抑制下hemichannel在细胞通讯调控作用,研究主要集中在:1)茧蜂病毒介导的hemichannel关闭与凋亡细胞形成凋亡小体的关系;2Hemichnanel在凋亡小体传递免疫抑制信号的作用;3)调控hemichannel在细胞通讯调控的害虫生物防治。

Connexin-hemichannel-脑转移-免疫反应相互作用机制

以云南宣威肺癌细胞的脑转移模式,研究Connexin-hemichannel在脑神经中枢的肿瘤免疫反应中的通讯调控机制,研究主要集中在:(1Hemichannel在宣威肺癌脑转移中的调控机制;(2Hemichannel在星形胶质细胞与肺癌细胞间的调控机制;(3)调控hemichannel在脑转移瘤细胞间的通讯机制,为肺癌脑转移的治疗提供实验基础。


实验室成员和在读研究生:

杨俊誉(讲师)(协助负责本科生的大创、国家级竞赛、毕业设计等实验管理)

代增美(养虫工人)

李明(副教授)(海燕策略研究中心方向细胞生物学与生物化学)

肖炜(研究员)(海燕策略研究中心方向微生物学/info/1011/2273.htm

张旭东(讲师)(负责本科生大创、国家级竞赛、毕业设计等)

在读研究生:黄永彪、乔鑫、马银陈、周理想、周赛军、袁永生、景睿、刘星衫、钟文峰、唐雪梅、何文政、张琼丽、郑鑫、赵悦轩


教授课程:

本科生课程:《Principles of Virology》,《食品安全纵横谈》。         

教育部病毒学重点领域教学资源共享平台

https://virology.spacekg.com/#/home

教育部昆虫病毒课程虚拟教研室

(虚拟教研室建设启动会召开https://mp.weixin.qq.com/s/6l97wIv1mVkoSIJs4B_kjQ


主要论文

*Corresponding authors  

# †These authors contributed equally to this work

1. Meng, Jiang-Hui#,Huang, Yong-Biao#,Long, Jin#,Cai, Qiu-Chen#,Qiao, Xin#,Zhang, Qiong-Li#,Zhang, Li-Dan,Yan, Xiang,Jing, Rui,Liu, Xing-Shan,Zhou, Sai-Jun,Yuan, Yong-Sheng,Ma, Yin-Chen,Zhou, Li-Xiang,Peng, Nan-Nan,Li, Xing-Cheng,Cai, Cheng-Hui,Tang, Hong-Mei,Martins, André F.,Jiang, Jean X.,Luo, Kai-Jun*. (2024)Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS. iScience, 10.1016/j.isci.2024.109469.https://www.sciencedirect.com/science/article/pii/S2589004224006904 (点评:云南大学罗开珺团队揭示茧蜂ecSOD降低寄主ROS的机制https://mp.weixin.qq.com/s/3JDnH5WQq8OvtB_4ZgCbrQ)

2. Xing-Cheng Li†, Yin-Chen Ma†, Jin Long†, Xiang Yan†, Nan-Nan Peng†, Cheng-Hui Cai†, Wen-Feng Zhong†, Yong-Biao Huang, Xin Qiao, Xiang-Li Zhou, Qiu-Chen Cai, Chang-Xu Cheng, Gui-Fang Zhou, Yun-Feng Han, Hong-Yu Liu, Qi Zhang, Hong-Mei Tang, Jiang-Hui Meng, Kai-Jun Luo*. (2023) Frontiers in Immunology. Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda. Frontiers in Immunology (2023) 14: doi:10.3389/fimmu.2023.1289477. https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289477 (点评:罗开珺团队揭示茧蜂一次精准寄生有效防治害虫的机制https://mp.weixin.qq.com/s/Buh6dxaOh9fxnJ27ZYWYFA)

3.Ming-Wu Dai, Kai-Jun Luo*. 2022Envelope-Fusion-Syncytium formation in Microplitis bicoloratus bracovirus maturation. Viruses, 2022,14,2183. https://doi.org/ 10.3390/v14102183.  https://www.mdpi.com/1999-4915/14/10/2183 (点评本科生大创自选项目揭示茧蜂病毒囊膜-融合-合胞体的成熟机 https://mp.weixin.qq.com/s/xB3F-PF99BrxP33_Y91jLA)

4. Jiang-Hui Meng#, Chang-Xu Chen#, Mohammad R. Ahmadian, Hong Zan, Kai-Jun Luo*, Jean X. Jiang*. Cross-activation of hemichannels/gap junctions and immunoglobulin-like domains in innate–adaptive immune responses. Frontiers in Immunology. 2022;13. doi:10.3389/fimmu.2023.882705. https://www.frontiersin.org/articles/10.3389/fimmu.2022.882706 (点评:罗开珺团队在细胞免疫领域取得新进展https://mp.weixin.qq.com/s/u0DdYTZPYtu3bER1xZAQbg

6. Gui-Fang Zhou#, Chang-Xu Chen#, Qiu-Chen Cai#, Xiang Yan#, Nan-Nan Peng#, Xing-Cheng Li#, Ji-Hui CuiYun-Feng HanQi ZhangJiang-Hui MengHong-Mei TangChen-hui CaiJin LongKai-Jun Luo*. (2022) Bracovirus sneaks into apoptotic bodies transmitting immunosuppressive signaling driven by integration-mediated eIF5A hypusination. Frontiers in Immunology 13. doi: 10.3389/fimmu.2022.901593. https://www.frontiersin.org/article/10.3389/fimmu.2022.901593 (点评:罗开珺团队揭示茧蜂病毒传递免疫抑制信号的新机制https://mp.weixin.qq.com/s/s5zg4qMveQVhzDl8FK15MQ)

7. Chang-Xu Chen#, Hao-Juan He#Qiu-Chen Cai#, Wei Zhang#, Tian-Chao KouXue-Wen ZhangShan You, Ya-Bin Chen, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo*. (2021) Bracovirus-mediated innexin-hemichannel closure in cell disassembly. iScience, doi: 10.1016/j.isci.2021.102281. https://www.ncbi.nlm.nih.gov/pubmed/33817584

8. Qiu-Chen Cai#, Chang-Xu Chen#, Hong-Yu Liu#, Wei Zhang#, Yun-Feng Han, Qi Zhang, Gui-Fang Zhou, Sha Xu, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo*. (2021) Interactions of Vank proteins from Microplitis bicoloratus bracovirus with host Dip3 suppress eIF4E expression. Dev Comp Immunol, 103994. doi:https://doi.org/10.1016/j.dci.2021.103994. https://www.ncbi.nlm.nih.gov/pubmed/33417999

9. Chang-Xu Chen, Kai-Jun Luo*, Jia-Peng Yang, Yun-Chao Huang*, Eduardo R. Cardenas, Bruce J. Nicholson, and Jean X. Jiang* (2021). Connexins and cAMP cross-talk in cancer progression and metastasis. Cancers (Basel) 13. DOI: 10.3390/cancers13010058. https://encyclopedia.pub/7122. https://www.ncbi.nlm.nih.gov/pubmed/33379194

10. Kai-Jun Luo*, Chang-Xu Chen, Jia-Peng Yang, Yun-Chao Huang *, Eduardo R. Cardenas, and Jean X. Jiang * (2020). Connexins in Lung Cancer and Brain Metastasis. Frontiers in Oncology 10. DOI:10.3389/fonc.2020.599383. https://www.frontiersin.org/article/10.3389/fonc.2020.599383

11. Ji-Hui Cui#, Shu-Mei Dong#, Chang-Xu Chen#, Wei Xiao#, Qiu-Cheng Cai, Li-Dan Zhang, Hao-Juan He, Wei Zhang, Xue-Wen Zhang, Tian Liu, Lei Ding, Yang Yang, Jian-Hua Lai, Qi-Shun Zhu, and Kai-Jun Luo*. (2019) Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura. Dev Comp Immunol 95, 101-107. https://www.ncbi.nlm.nih.gov/pubmed/30776419

10. Li-Dan Zhang #, Qiu-Cheng Cai #, Ji-Hui Cui #, Wei Zhang #, Shu-Mei Dong #, Wei Xiao #, Jiang Li, Tian-Chao Kou, Xue-Wen Zhang, Hao-Juan He, Lei Ding, Yang Yang, Jian-Hua Lai, Ming Li, Qi-Shun Zhu, Kai-Jun Luo*. (2019) A secreted-Cu/Zn superoxide dismutase from Microplitis bicoloratus reduces reactive oxygen species triggered by symbiotic bracovirus. Dev Comp Immunol 92, 129-139. https://www.ncbi.nlm.nih.gov/pubmed/30471301

12. Ji-Hui Cui #, Yan-Bin Chen #, Ming Li #, Qiu-Cheng Cai, Li-Dan Zhang, Zi-Yun Lu, Jian-Cheng Li, Qi-Shun Zhu, Gang Ji *, Kai-Jun Luo*. (2018) Cryo-EM structure reveals cylindrical nucleocapsids from two polydnaviruses. Arch Virol 163, 3357-3363. https://www.ncbi.nlm.nih.gov/pubmed/30173353

13. Wei Zhang #, Meng-Wei Liu #, Ming Li #, Wei Xiao #, Xue-Wen Zhang Hao-Juan He, Yan-Bin Chen, Lei Ding, Kai-Jun Luo*. (2018) Unexpected link between insect innexins and apoptosis of HeLa cells. Arch Insect Biochem Physiol 99, e21473. https://www.ncbi.nlm.nih.gov/pubmed/29862562

14. Shu-Mei Dong, Ji-Hui Cui, Wei Zhang, Xue-Wen Zhang, Tian-Chao Kou, Qiu-Chen Cai, Sha Xu, Dong-Shuai Yu, Lei Ding, Jian-Hua Lai, Ming Li, Kai-Jun Luo*. (2017). Inhibition of translation initiation factor eIF4A is required for apoptosis mediated by Microplitis bicoloratus bracovirus. Arch Insect Biochem Physiol 96, e21423. https://www.ncbi.nlm.nih.gov/pubmed/28940716

15. Tian-Chao Kou #, Yue-Tong Liu #, Ming Li #, Yang Yang #, Wei Zhang, Ji-Hui Cui, Xue-Wen Zhang, Shu-Mei Dong, Sha Xu, Shan You, Dong-Shuai Yu, Zun-Yu Pang, Kai-Jun Luo*. (2017). Identification of β-chain of FoF1-ATPase in apoptotic cell population induced by Microplitis bicoloratus bracovirua and its role in the development of Spodoptera litura. Arch Insect Biochem Physiol 95, e21389. https://www.ncbi.nlm.nih.gov/pubmed/28557004

16. Dong-Shuai Yu #, Ya-Bin Chen #, Ming Li #, Ming-Jun Yang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). A polydnaviral genome of Microplitis bicoloratus bracovirus and molecular interactions between the host and virus involved in NF-κB signaling. Arch Virol 161, 3095-3125. https://www.ncbi.nlm.nih.gov/pubmed/27522588

17. Ya-Bin Chen #, Wei Xiao #, Ming Li #, Yan Zhang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). N-terminally elongated SpliInx2 and SpliInx3 reduce baculovirus-triggered apoptosis via hemichannel closure. Arch Insect Biochem Physiol 92, 24-37. https://www.ncbi.nlm.nih.gov/pubmed/27030553

18. Lin-E Guo #, Jun-Feng Zhang #, Xin-Yi Liu, Li-Mei Zhang, Hong-Li Zhang, Jian-Hua Chen, Xiao-Guang Xie, Ying Zhou*, Kai-Jun Luo*, Ju-Yong Yoon*. (2015) Phosphate ion targeted colorimetric and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell. Anal Chem 87, 1196-1201. https://www.ncbi.nlm.nih.gov/pubmed/25511872

19. Zunyu Pang #Ming Li #Dongshuai Yu #Yan ZhangXinyi LiuXinglai JiYang YangJiansheng HuKaijun Luo*. (2015). Two innexins of Spodoptera litura influences hemichannel and gap junction functions in cellular immune responsesArch Insect Biochem Physiol 90, 43-57. https://www.ncbi.nlm.nih.gov/pubmed/25939810

20. Ming Li #Zunyu Pang #Wei Xiao #Xinyi LiuYan ZhangMinjun YangYang YangJiansheng HuKaijun Luo*. (2014). A Transcriptome analysis Suggests apoptosis-related signaling pathways in hemocytes of Spodoptera litura after parasitization by Microplitis bicoloratusPLoS ONE 9(10),1-18, e110967. https://www.ncbi.nlm.nih.gov/pubmed/25350281

21. Tian Liu #Ming Li #Yan ZhangZunyu PangWei XiaoYang YangKaijun Luo*. (2013). A role for Innexin2 and Innexin3 proteins from Spodoptera litura in apoptosis, PLoS ONE, 8(7), e70456. https://www.ncbi.nlm.nih.gov/pubmed/23936205